Luke Chung took the course as a freshman in 1981, the first year it was taught. Wasn't even called CS 50 then, because there weren't any "Computer Science" courses as such–the original name was Applied Sciences 11. It didn't turn him into a CS concentrator (actually, there was no CS concentration then, but he didn't concentrate in Applied Math either). He has gone on to a three-decade-long career as president of his own software development firm, FMS Inc.
He is now widely quoted on the technology failures of the Affordable Care Act web site and will be testifying on Wednesday before the House Homeland Security committee about possible security issues with the site. Big deal! Break a leg, Luke.